Bravo et merci \u00e0 Charlie Colin Pierre et ses collaborateurs de l’\u00e9quipe de St\u00e9phane Brezillon (Universit\u00e9 de Reims Champagne-Ardenne, Laboratoire MEDyC, CNRS UMR 7369) pour cette revue tr\u00e8s compl\u00e8te en open access dans \u00ab\u00a0Regenerative Medicine\u00a0\u00bb.\u00a0 Colin-Pierre C, El Baraka O, Danoux L, Bardey V, Andr\u00e9 V, Ramont L, Br\u00e9zillon S. NPJ Regen Med. 2022 Dec 28;7(1):77. https:\/\/doi.org\/10.1038\/s41536-022-00267-y PMID: 36577752.<\/p>\n
Heparan sulfate proteoglycans (HSPGs) are part of proteoglycan family.\u00a0They are composed of heparan sulfate (HS)-type glycosaminoglycan (GAG) chains covalently linked to a core protein. By interacting with growth factors and\/or receptors, they regulate numerous pathways including Wnt, hedgehog (Hh), bone morphogenic protein (BMP) and fibroblast growth factor (FGF) pathways. They act as inhibitor or activator of these pathways to modulate embryonic and adult stem cell fate during organ morphogenesis, regeneration and homeostasis. This review summarizes the knowledge on HSPG structure and classification and explores several signaling pathways regulated by HSPGs in stem cell fate. A specific focus on hair follicle stem cell fate and the possibility to target HSPGs in order to tackle hair loss are discussed in more dermatological and cosmeceutical perspectives.<\/p>\n
<\/p>\n
<\/p>\n