{"id":861,"date":"2012-05-30T00:05:56","date_gmt":"2012-05-29T23:05:56","guid":{"rendered":"http:\/\/www.sfbmec.fr\/?p=861"},"modified":"2016-12-12T01:06:13","modified_gmt":"2016-12-12T01:06:13","slug":"jean-claude-monboisse-2","status":"publish","type":"post","link":"https:\/\/www.sfbmec.fr\/?p=861","title":{"rendered":"Jean-Claude Monboisse"},"content":{"rendered":"<p><iframe loading=\"lazy\" src=\"http:\/\/www.dailymotion.com\/embed\/video\/xqe8gu\" width=\"560\" height=\"315\" frameborder=\"0\"><\/iframe><br \/>\n<a href=\"http:\/\/www.dailymotion.com\/video\/xqe8gu_jean-claude-monboisse_tech\" target=\"_blank\">Jean-Claude Monboisse<\/a> <em>by <a href=\"http:\/\/www.dailymotion.com\/SINGER-POLIGNAC\" target=\"_blank\">SINGER-POLIGNAC<\/a><\/em><\/p>\n<p><strong>Matrikines: a new anticancer therapeutic strategy<\/strong><\/p>\n<p><strong>Jean Claude Monboisse<\/strong><\/p>\n<p>Tumor microenvironment is a complex system of a largely altered extracellular matrix with different cell types that influence the angiogenic response to a tumor and the local invasion of the tumor. Upon the influence of hypoxia, tumor cells secrete cytokines that activate stromal cells to produce proteases and angiogenic factors. The proteases degrade the stromal ECM and participate in the release of various ECM fragments, named matrikines or matricryptins, capable to control tumor invasion and metastasis dissemination. We will focus on the matrikines derived from the NC1 domains of the different constitutive chains of basement membrane-associated collagens and mainly collagen IV. The putative targets of the matrikine action are the proliferation and invasive properties of tumor or inflammatory cells, and the angiogenic and lymphangiogenic responses. For example, canstatin, tumstatin and tetrastatin, respectively derived from the NC1 domains of \u03b12, \u03b13 and \u03b14 chains of collagen IV, inhibit\u00a0<em>in vivo<\/em>\u00a0tumor growth in various experimental cancer models. Their anti-cancer activity comprises an anti-proliferative effect on tumor cells and on endothelial cells by induction of cell apoptosis or cell cycle blockade and the induction of a loss of their migratory phenotype.<\/p>\n<p>Matrikines constitute a new family of potent anticancer agents that could be used under various therapeutic strategies: i) induction of their overexpression by cancer cells or by the host cells, ii) use of recombinant proteins or synthetic peptides or structural analogs designed from the structure of the active sequences. These matrikines could be used in combination with conventional chemotherapy or radiotherapy.<\/p>\n<div class=\"sharedaddy sd-sharing-enabled\"><div class=\"robots-nocontent sd-block sd-social sd-social-icon-text sd-sharing\"><h3 class=\"sd-title\">Partager :<\/h3><div class=\"sd-content\"><ul><li class=\"share-email\"><a rel=\"nofollow noopener noreferrer\" data-shared=\"\" class=\"share-email sd-button share-icon\" href=\"https:\/\/www.sfbmec.fr\/?p=861&amp;share=email\" target=\"_blank\" title=\"Cliquez pour envoyer par e-mail \u00e0 un ami\"><span>E-mail<\/span><\/a><\/li><li class=\"share-twitter\"><a rel=\"nofollow noopener noreferrer\" data-shared=\"sharing-twitter-861\" class=\"share-twitter sd-button share-icon\" href=\"https:\/\/www.sfbmec.fr\/?p=861&amp;share=twitter\" target=\"_blank\" title=\"Cliquez pour partager sur Twitter\"><span>Twitter<\/span><\/a><\/li><li class=\"share-facebook\"><a rel=\"nofollow noopener noreferrer\" data-shared=\"sharing-facebook-861\" class=\"share-facebook sd-button share-icon\" href=\"https:\/\/www.sfbmec.fr\/?p=861&amp;share=facebook\" target=\"_blank\" title=\"Cliquez pour partager sur Facebook\"><span>Facebook<\/span><\/a><\/li><li class=\"share-linkedin\"><a rel=\"nofollow noopener noreferrer\" data-shared=\"sharing-linkedin-861\" class=\"share-linkedin sd-button share-icon\" href=\"https:\/\/www.sfbmec.fr\/?p=861&amp;share=linkedin\" target=\"_blank\" title=\"Cliquez pour partager sur LinkedIn\"><span>LinkedIn<\/span><\/a><\/li><li class=\"share-end\"><\/li><\/ul><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Jean-Claude Monboisse by SINGER-POLIGNAC Matrikines: a new anticancer therapeutic strategy Jean Claude Monboisse Tumor microenvironment is a complex system of a largely altered extracellular matrix with different cell types that influence the angiogenic response to a tumor and the local &hellip; <a href=\"https:\/\/www.sfbmec.fr\/?p=861\">Continuer la lecture <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n<div class=\"sharedaddy sd-sharing-enabled\"><div class=\"robots-nocontent sd-block sd-social sd-social-icon-text sd-sharing\"><h3 class=\"sd-title\">Partager :<\/h3><div class=\"sd-content\"><ul><li class=\"share-email\"><a rel=\"nofollow noopener noreferrer\" data-shared=\"\" class=\"share-email sd-button share-icon\" href=\"https:\/\/www.sfbmec.fr\/?p=861&amp;share=email\" target=\"_blank\" title=\"Cliquez pour envoyer par e-mail \u00e0 un ami\"><span>E-mail<\/span><\/a><\/li><li class=\"share-twitter\"><a rel=\"nofollow noopener noreferrer\" data-shared=\"sharing-twitter-861\" class=\"share-twitter sd-button share-icon\" href=\"https:\/\/www.sfbmec.fr\/?p=861&amp;share=twitter\" target=\"_blank\" title=\"Cliquez pour partager sur Twitter\"><span>Twitter<\/span><\/a><\/li><li class=\"share-facebook\"><a rel=\"nofollow noopener noreferrer\" data-shared=\"sharing-facebook-861\" class=\"share-facebook sd-button share-icon\" href=\"https:\/\/www.sfbmec.fr\/?p=861&amp;share=facebook\" target=\"_blank\" title=\"Cliquez pour partager sur Facebook\"><span>Facebook<\/span><\/a><\/li><li class=\"share-linkedin\"><a rel=\"nofollow noopener noreferrer\" data-shared=\"sharing-linkedin-861\" class=\"share-linkedin sd-button share-icon\" href=\"https:\/\/www.sfbmec.fr\/?p=861&amp;share=linkedin\" target=\"_blank\" title=\"Cliquez pour partager sur LinkedIn\"><span>LinkedIn<\/span><\/a><\/li><li class=\"share-end\"><\/li><\/ul><\/div><\/div><\/div>","protected":false},"author":1,"featured_media":903,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"spay_email":""},"categories":[8],"tags":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p3JW17-dT","_links":{"self":[{"href":"https:\/\/www.sfbmec.fr\/index.php?rest_route=\/wp\/v2\/posts\/861"}],"collection":[{"href":"https:\/\/www.sfbmec.fr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sfbmec.fr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sfbmec.fr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sfbmec.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=861"}],"version-history":[{"count":1,"href":"https:\/\/www.sfbmec.fr\/index.php?rest_route=\/wp\/v2\/posts\/861\/revisions"}],"predecessor-version":[{"id":2215,"href":"https:\/\/www.sfbmec.fr\/index.php?rest_route=\/wp\/v2\/posts\/861\/revisions\/2215"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sfbmec.fr\/index.php?rest_route=\/wp\/v2\/media\/903"}],"wp:attachment":[{"href":"https:\/\/www.sfbmec.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=861"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sfbmec.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=861"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sfbmec.fr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=861"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}