Cell / microenvironment cross-talk and tissue repair lab
Biologie Tissulaire et Ingénierie Thérapeutique Department
UMR 5305 – CNRS/UCB Lyon 1- SFR BioSciences Gerland-Lyon Sud
7 passage du Vercors – 69367 Lyon Cedex 07, France
Phone: 33 (0)4 72 72 26 39 | | Fax: 33 (0)4 72 72 26 02
Email address : firstname.lastname@example.org
Patricia Rousselle is research director at CNRS in France where she leads a lab in the Tissue Biology and Therapeutic Engineering Department of the Institute of Protein Biology and Chemistry in Lyon. This department is one of the major centres in France specialising in the extracellular matrix and tissue repair field of research. Developing both biochemical and cell biology approaches, her group is interested in analysing the behaviour of keratinocytes during the reepithelialisation phase of wound repair and their interaction with extracellular matrix components. Besides, she develops translational research through collaborations with clinicians of the Lyon Burn Centre and industrial partners. Patricia is the present president of the French Matrix Society and is also a board member of the European Tissue Repair Society. Patricia obtained a doctorate in Pharmacy in 1988 and pursued a four-year residency in clinical biology at Lyon Hospitals, where she also gained an MSc in Molecular and Cellular Biology in 1990. Being interested in adhesion mechanisms of the epidermis, she started a PhD program with Prof Bob Burgeson at the Shriners Hospital For Crippled Children in Portland, USA, where she discovered the important dermal epidermal junction protein laminin 332. She thereafter joined the Cutaneous Biology Research Center in Boston, USA, to work on basement membrane biology, before she joined CNRS to set up her own group in 1995. Patricia Rousselle has published more than 90 articles on extracellular matrix proteins with a focus on laminins and proteoglycans, in internationally renowned journals. Dr. Rousselle’s special research interests include the role of basement membrane components and cell receptors, such as syndecans, in epithelial homeostasis and repair.
Secrétaire général (bureau)
UMR CNRS/URCA 7369 MEDyC
Responsable de l’équipe « Protéolyse et Cancer » – Laboratoire « Signalisation et Récepteurs Matriciels »
UFR Sciences Exactes et Naturelles – Bât. 18 RDC, bureau BR 21
Campus du Moulin de la Housse, BP 1039 – Chemin des Rouliers – 51687 REIMS Cedex 2
Tel: +33 (0)3 26 91 83 61
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Hervé Emonard is associate scientist at CNRS in France where he leads the Proteolysis and Cancer Team of the UMR 7369 CNRS/URCA in Reims. Our unit is the leader in France for investigating the cytokine-like effects of degradation products, the matrikines, from two major components of the extracellular matrix, collagen and elastin. These matrikines are essentially studied in tumoral and vascular pathologies. Hervé is the present secretary of the French Extracellular Matrix Society.
Hervé obtained his PhD in 1984 at Lyon. A two-year post-doctoral fellowship in the laboratory of Profs Charles M. Lapière and Jean-Michel Foidart (University of Liege, Belgium) allowed him to familiarize himself with a family of proteolytic enzymes degrading extracellular matrix, the matrix metalloproteinases, MMPs. He joined CNRS in 1986 to study the extracellular matrix breakdown during hepatic fibrosis in Lyon. Then he moved to Reims in 1995, in the CNRS unit of Prof. François-Xavier Maquart to set up a group studying mechanisms of MMP inhibition with Prof. William Hornebeck. Hervé developped a strong collaboration with Prof. Pierre J. Courtoy (de Duve Institute, UCL, Brussels, Belgium) to understand the regulation of MMP extracellular levels by LRP-1-mediated endocytosis. Hervé Emonard has published more than 70 articles on the regulation of MMP activities, with a focus on MMP-2 and LRP-1.
Dynamique du Microenvironnement et Cancer
IRSET, Institut de Recherche en Santé, Environnement et Travail
2 avenue du Professeur Léon Bernard – 35043 Rennes Cédex
Tel: +33 (0)223 23 48 11
Email address: nathalie.theret@univ‐rennes1.fr
Nathalie Théret is research Director at INSERM in France where she heads a research team at the Research Institute in Health, Environment and work (IRSET) supported by INSERM and University of Rennes 1. IRSET’s mission is to study biological processes and environmental factors that influence human health. Using multi-scale approaches combining molecular and cellular biology, biophysical and computational methods, her group is interested in studying extracellular matrix (ECM) remodeling in chronic liver diseases. Studies focus on the role of disintegrins and metalloproteases (ADAM) on TGF‐β signaling, the effects of ECM stiffness on hepatocyte functionality and the identification of a structure‐based signature for liver fibrosis evaluation by multiphotonic microscopy. Nathalie is the present treasury of the French Extracellular Matrix Society. Nathalie obtained her PhD in Pharmaceutic sciences in 1988 and pursued a two‐year post‐doctoral position in the laboratory of Pr Fruchart at Pasteur Institute (Lille) where she studied reverse cholesterol transport in cardiovascular diseases. She joined INSERM in 1991 and managed the «BioAvenir» Research Program in collaboration with Rhone Poulenc Roher Corporation focusing on the role of AI and AIV apolipoproteins. Next she moved in 1993 to the INSERM Unit directed by Pr Guillouzo (University of Rennes) and joined Dr B.Clement’s team to develop studies on extracellular matrix remodeling in liver cancers. To address the biological complexity of liver fibrosis and tumor progression, she sets up her own group in 2007 and develops systemic approaches for high-throughput data analysis and molecular modeling in collaboration with the Research Institute in Computational Research (INRIA). Nathalie Théret has published more than 70 articles and her research interests include ADAM proteins, TGFβ signaling and fibrosis.
UMR CNRS/URCA 7369 MEDyC
Laboratoire de Biochimie Médicale et Biologie Moléculaire
51 Rue Cognacq-Jay
Phone: +33 (0)3 26 91 37 34 | | Fax: +33 (0)3 26 91 80 55
Email address: firstname.lastname@example.org
Stéphane Brézillon is associate scientist at CNRS in France where he leads with Prof. S. Dedieu the “ExtraCellular Matrix, Cancer and Therapeutic Targets” Team of the Research Unit MEDyC URCA/CNRS UMR 7369 in Reims.
Our unit is the leader in France for investigating the cytokine-like effects of degradation products, the matrikines, from major components of the extracellular matrix, collagen, elastin and proteoglycans. These matrikines are essentially studied in tumoral and vascular pathologies. Our team is focusing on LRP-1-mediated endocytosis and extracellular vesicles mediated cell communication between tumor cells, endothelial cells, and fibroblasts.
Stéphane Brézillon has obtained his Joint PhD in 1997 at Reims (Dr E. Puchelle (INSERM U514, University of Medicine, Reims, France) and at Hannover (Pr B. Tümmler (Klinische Forschergruppe, Medizinische Hochschule Hannover, Germany). After a two-year post-doctoral fellowship in the laboratory of Prof G. Cramb (Saint Andrews, Scotland, UK), he became project leader in a biotechnology company, Euroscreen, Brussels, Belgium (1999-2004). Then, he moved to Reims in 2004 in the CNRS unit of Prof. François-Xavier Maquart to set up a group with Dr Y. Wegrowski studying the mechanisms of action of Lumican, a Small Leucine Rich Proteoglycan, able to inhibit melanoma progression. Using integrative technologies from Biochemistry, Cell Biology, Imaging, in vivo murine models (WT and lumican deleted mice) and in silico approaches (developed in collaboration with Pr. Manuel Dauchez’s group, UMR CNRS 7369), he extensively studied the signaling pathways, the mechanisms of action, and the modeling of Lumican with its receptors. He is developing a strong collaboration with Prof. Karamanos (University of Patras, Greece) and Prof. M. Gotte (University of Munster, Germany) and he belongs to the H2020 GLYCANC consortium.
Stéphane Brézillon has published more than 40 articles with a focus on lumican mechanism of action and its interaction with alpha2beta1 integrin and MMP-14.
Université de Cergy Pontoise, ERRMECe, EA1391, Groupe MEC-uP
UFR Science et Technique
2 Av. Adolphe Chauvin
95302 CERGY-PONTOISE Cedex
Phone: +33 (0)1 34 25 66 75 | | Fax: +33 (0)1 34 25 66 94
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Franck Carreiras is professor at the University of Cergy Pontoise and member of the ERRMECe lab
In 1996, Franck obtained his PhD from the University of Caen in the unit of Biology and Innovative Therapies on the locally Aggressive Cancers, UMR INSERM 1199, BioTICLA of the F. Baclesse center. He then was a post-doc of the University of Aix-Marseille-II before being recruited at the University of Cergy Pontoise in 1998 as assistant professor. He obtained the habilitation degree in 2006 and got a Professor position in 2011.
He is now the leader of the group MEC-uP (Extracellular Matrix and Physiopathology) of the ERRMECe lab. Since the beginning, his general concern aims at positioning the matrix microenvironment in the center of his investigations. His recruitment at Cergy Pontoise allowed him to set up within the University a long-lasting theme concerning the influence of the matrix microenvironment on the tumoral dissemination. Since his nomination as leader of the MEC-uP group he continues this work on the tumoral microenvironment and the metastatic dissemination while diversifying his projects according to the knowledge of each members of his group (cellular ageing, tissue repair, surfaces functionalization). The characterization of the matrix microenvironment and its regulating impact on cellular activities stays at the center of his research. Franck Carreiras has published 40 articles, he directed 6 PhD and is also the director of the Master’s degree called BioC2M “Cellular and Molecular Biology of the Microenvironment”.
UMR CNRS / URCA 7369 – « Extracellular Matrix and Cell Dynamics » (MEDyC)
Team 2 « Matrix Aging and Vascular Remodeling »
UFR Sciences Exactes et Naturelles – Campus Moulin de la Housse
51687 REIMS Cedex 2
Phone: +33 (0)3 26 91 89 39
Email address: firstname.lastname@example.org
Laurent Duca is Professor at the University of Reims Champagne-Ardenne where he leads with Pr. Philippe Gillery a team dealing with Matrix Aging and Vascular Remodeling. This team belongs to the CNRS associated research unit UMR CNRS/URCA 7369 MEDyC, a major lab in France specialized in cell/extracellular matrix interactions studies in pathophysiological contexts such as aging and cancer. He is interested in the molecular mechanisms leading to vascular elastolysis and in the role played by elastin-derived peptides (EDP) in the development of vascular diseases such as atherosclerosis. Using integrative technologies from Biochemistry, Cell Biology, Imaging, in vivo murine models (WT or transgenic) and in silico approaches (developed in collaboration with Pr. Manuel Dauchez’s group, UMR CNRS 7369), he extensively studied the signaling pathways and the operating mechanism of the Elastin Receptor Complex (ERC). The data gathered allowed him to propose a new pharmacology targeting the ERC and permitting to limit the deleterious involvement of elastin peptides in pathological vascular remodeling. His team also develops thematic dealing with the role of EDP in diabetes outcome, regulation of thrombosis and new molecular therapeutic approaches targeting the ERC. Moreover, a research axis on non enzymatic post-translational modifications of extracellular matrix proteins (carbamylation, glycoxydation) and their implication during aging is also developed (leading by Pr. Philippe Gillery).
Laurent Duca obtained his PhD in Biochemistry and Molecular Biology in 2004 at the University of Reims Champagne-Ardenne. He then performed a post-doctoral training in Toulouse at INSERM and Pierre Fabre laboratories where he studied molecular genetics approaches to modulate pathological cutaneous and corneal wound healing. He then joined his current lab as Associate Professor. He has published more than 40 articles in internationally renowned journals with a primary focus on elastin, elastin-derived peptides and the Elastin Receptor Complex.
“Tumor signaling-Integrin and cancer” team
Laboratory of Biophotonics and Pharmacology, CNRS UMR7213
University of Strasbourg
Faculty of Pharmacy, 74 route du Rhin
Phone: +33 (0)3 68 85 41 92 | | Fax: +33 (0)3 68 85 43 13
Email address: email@example.com
Maxime Lehmann is Professor in Cell Biology at the Faculty of Pharmacy of the Strasbourg University. Maxime was appointed Professor in 2011 when in joined the group “Integrin and cancer” from the Laboratory of Biophotonics and Pharmacology. This group is interested on the role of integrins, a major class of extracellular matrix receptors in cancer resistance to therapies. Maxime obtained a PhD in Biochemistry and Microbiology in 1994 in Marseille. During his PhD, he developed one of the first function-blocking antidody against the αv integrin family. Thereafter, he pursued a 3-years post-doc at the department of Pathology of Montreal University in Pr Lisa McKerracher’s team where he worked on the role of laminin and integrin in neuronal growth cone motility. He discovered the central role of Rho GTPases in axonal regrowth inhibition after CNS injury. Thereafter, he joined Aix-Marseille University as an assistant professor (Center for Research in Oncology and Oncopharmacology) where he worked on the role of integrins in colon carcinoma cell invasion. He also established partnerships with private companies to study epidermal wound healing. Currently, Maxime worked on the role of the integrin fibronectin receptor on glioblastoma cell invasion and resistance to targeted therapies. Maxime has published 40 papers in international renowned journals and is authors of two patents.
11 rue Edison
Phone: +33 (0)4 78 61 46 31 | | Fax: +33 (0)4 78 61 46 32
Email address: firstname.lastname@example.org
Aurélie Pagnon obtained a doctorate in Cellular and Molecular Biology in 2007. She began a PhD program with Dr. Florence Ruggiero at the Institute of Protein Biology and Chemistry of Lyon where she worked on collagens and their role in the development. After her thesis, she became Project Manager at Organogenesis Inc. (Canton, Mass., USA) where she performed in vitro studies to characterize a new generation of skin engineered products. She studied the biocompatibility, the integration and the biodegradability of biomaterials or of reconstructed skins by histology, immunohistochemistry, in situ hybridization and electron microscopy.
In 2010, she joined the NOVOTEC Society where she became R&D and Expertise’s Manager. Established at Bron (69) inside the activity zone of « Parc du Chêne », Novotec is situated near big scientific poles of the region of Lyon. Founded in 1997 by researchers of the Institut Pasteur of Lyon, Novotec is specialist in production and distribution of specific antibodies against the extracellular matrix macromolecules (collagens, elastin, fibronectin, laminin…). The improved knowledge of histological and immunohistochemical methods makes Novotec an expert in the tissue characterization. As a service provider, Novotec offers its expertise to the industrialists and the private or academic research laboratories (biotechnologies, pharmaceutics, bio-diagnosis, food processing industry, cosmetics, veterinary, tissue engineering…). Novotec also develops research programs on cutaneous and cartilage tissue engineering, in collaboration with French and foreign companies.
Equipe n°2 : Génomique fonctionnelle et traitements des métastases osseuses
7-11 rue Guillaume Paradin
69372 LYON Cedex 08
Phone: +33 (0)4 78 78 57 38
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Caroline Reynaud is senior scientist at CNRS in France where she leads the Lysyl oxidases and bone metastases group at the UMR 1033 INSERM/UCBL in Lyon. This unit is a major lab in France specialized in bone physiopathology. One of their objectives is to identify the underlying molecular mechanisms governing the nesting of tumor cells in the bone marrow and those that favor the formation of medullary micrometastases, the prelude required for bone metastasis formation. Additionally, they develop new biological markers of early relapse of cancer in bone will and test novel therapeutics in animal models of malignant bone diseases.
Caroline obtained her PhD in 2000 at the Ecole Normale Supérieure of Lyon. Her three-year post-doctoral fellowship on cell cycle in the laboratory of Prof Robert Margolis (IBS, Grenoble), led her to published important papers on the regulation of cell cycle checkpoints during tumor progression. She was recruited at the CNRS in 2003 in Pascal Sommer’s lab (IBCP, Lyon) to work on Lysyl oxidases and skin tumors. Then she moved to UMR1033 to study the role of Lysyl oxidases in the formation of the premetastatic niche into the bone marrow. Caroline has published more than 20 papers in renowned international journals.
Institut de Génomique Fonctionnelle de Lyon, CNRS UMR 5242,
Ecole Normale Supérieure de Lyon
Université Claude Bernard Lyon 1,
46 allée d’Italie
Phone: +33 (0)4 26 73 13 58
Email address: firstname.lastname@example.org
Florence Ruggiero is Director of Research at the CNRS. She leads a a team “Matrix Biology and Pathology Institute of Functional Genomics of Lyon. Since January 2016, she also serves as the Director of the IGFL. Her training background combines cell biology, molecular biology, microscopies, biochemistry and development. Her primary research interest, as a young investigator at the CNRS, was the analysis of cell-collagen interactions. For that, she developed new methods to produce recombinant full-length collagens and derived-domains in different expression systems including plants. Since then, the super family of collagens became “her family” and she has now 30 years of experience in matrix biology research. In 2003, she started to run her independent group at the Institute of Protein Chemistry and Protein (IBCP, Lyon). Since then, the analysis of collagen function in model organisms was at the core of her research. Because collagens form intricate network in tissues, predicting their function is difficult. Her main objective was to understand the diversity of collagen functions from molecules to integrative systems using cell and animal models. In parallel, from 2006 to 2010, she successively held the position of vice-director and then director of the SFR-Bioscience-Gerland (UMS3444/US8). In 2011, her team moved to the Institute of Functional Genomics of Lyon (IGFL, ENSL), a new institute of the Ecole Normale Supérieure de Lyon, interested in evolution, development and integrative physiology using functional genomics. During the last years, her group have explored the amazing functional diversity of collagen genes during development and analyzed possible links between defective collagen function and human diseases, using combined approaches including functional genomics, biochemistry, cell biology and integrative biology. Her lab is currently interested in unraveling the function of collagens in development, tissue regeneration and rare connective tissue disease as the classic Elhers-Danlos syndrome and neuromuscular disorders associated to collagen deficiency. Florence Ruggiero has published more than 90 publications and reviews in the Matrix Biology field. Recently, she was honored to serve as Chair for the 2017 Collagen Gordon Research Conference.
Représentante étudiant invitée (Titulaire)
Centre Interdisciplinaire de Recherches en Biologie (CIRB)
INSERM U1050, Collège de France
Phone: +33 (0)1 44 27 15 87
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I am a 3rd year PhD student at the Centre Interdisciplinaire de Recherche en Biologie at College de France in Paris. I joined the « Matrix proteins in hypoxia and angiogenesis » lab headed by Stephane Germain in 2016 in the context of my master training period. My team is interested in understanding how angiogenesis and vascular integrity are regulated by extracellular matrix modifying enzymes. I pursued a bachelor’s degree at Sorbonne Université and performed a master’s degree entitled « Integrative biology » between 2014 and 2016 and started my PhD program in October 2016 under Laurent Muller supervision. My PhD project focuses on the role of extracellular matrix remodeling in endothelial mechanotransduction. I am particularly interested in understanding cell-matrix relationships using several approaches based on 3D cell culture models and zebrafish embryos, using proteomics studies, molecular biology, and various imaging tools including confocal, light sheet and atomic force microscopy. I was elected as a student representative at SFBMEc board since January 2019 and I aim to present students wishes and aspirations in SBMEc board meetings and to inform students about SFBMEc board activities and decisions.
Représentante étudiant invitée (Suppléante)
UMR CNRS / URCA 7369 – « Extracellular Matrix and Cell Dynamics » (MEDyC)
Team 2 « Matrix Aging and Vascular Remodeling »
UFR Sciences Exactes et Naturelles – Campus Moulin de la Housse
51687 REIMS Cedex 2
Phone: +33 (0)3 26 91 86 23
Email address: firstname.lastname@example.org
I’m a 1rst year PHD Student at the University of Reims Champagne-Ardenne in a team dealing with Matrix Aging and Vascular remodeling lead by her directors Pr. Laurent Duca and Dr Stéphane Jaisson. I joined this team during my master training period. This team studying extracellular matrix components especially elastin and its role during aging and the development of diseases. Thus, my PhD project focuses on the role of elastin derived peptides carbamylated or not on the evolution of atheroma plaques and the development of atherosclerosis.
After a dietician diploma, I pursued my studies with a bachelor’s degree in Biology and Biochemistry at the Sciences University of Reims. Then, I performed a master’s degree in research in biology and health and started my PhD program in October 2018. I joined the SFBMEc board as a student representative substitute. Marion Marchand and I represent the student in the SFBMEc board meetings and inform them about activities and decisions.
Décédé le 9 janvier 2019 dans sa 88ème année.
Hôpital St Louis
1 avenue Claude Vellefaux
75475 PARIS Cedex 10
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UMR 5246 CNRS/Université Lyon 1
43 Boulevard du 11 Novembre
69622 VILLEURBANNE Cedex
Phone: +33 (0)4 72 44 82 32
Email address: firstname.lastname@example.org
Décédé le 6 janvier 2018 dans sa 94ème année.
Dernière mise à jour : 10/10/2018.