Archives de catégorie : Publications

Heparan-mimetics: Potential agents of tissue regeneration for bone andperiodontal therapies

Maroun Bou Karam, Joe El Khoury, Carole Chakar, Sylvie Changotade, Didier Lutomski, Nada Naaman, Gaston Godeau, Abdellatif Elm’selmi, Ronald Younes, Karim Senni


Heparan sulfate glycosaminoglycans are key players of tissue repair and can be regarded as useful compounds for regenerative medicines. Unfortunately, their therapeutic uses face many technical, industrial, and regulatory hurdles due to their animal origin. So, some non-animal sulfated polysaccharides mimic heparan sulfate properties and offer interesting solutions to replace them. Among them, dextran derivatives, seaweed polysaccharides, or marine bacterial polysaccharides are the best known and have demonstrated their pro-regenerative capabilities
by promoting both extracellular matrix structuring and angiogenesis and limiting degenerative processes such as inflammatory cell migration or tissue proteolysis. These polysaccharides have also shown their ability to specifically promote osteoblastic differentiation and bone wound healing. Furthermore, recent works shows that heparan-mimetics can be used as an additive to improve the cytocompatibility of bone substitutes commonly used in periodontal surgery. The use of these polysaccharides can be regarded as a clever approach to improve the
biointegration of bone substitutes.

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Dear colleagues,

The special issue given below is online.
Thanks to the contributions by well known authors in the field,  another key area of matrix biology has been published.
Many thanks to editor-in-chief Renato Iozzo for giving us the  opportunity and his great support during all steps of this endeavor !

I hope it will be a useful for your future research.
All the best

Matrix Biology
Volume 75, Pages 1-330, January 2019
Matrix Modeling and Remodeling
Edited by Nikos Karamanos

December issue of Matrix Biology related with the 2nd Matrix Biology Europe Conf. is out

Dear Colleagues and friends,

This is to inform you that, thanks to the editor-in-chief Dr. Renato Iozzo, the December issue of Matrix Biology includes the « Matrix Biologists in Action” related with the 2nd Matrix Biology Europe Conference, held in Athens last june 2016.

The article could be downloaded here.

I hope you will enjoy it.

All the best
Nikos Karamanos

Publication eBook « Matricellular Receptors as Potential Targets in Anti-Cancer Therapeutic Strategies »

couverture-ebook-1Hervé Emonard, Stéphane Dedieu et Laurent Duca ont le plaisir de vous annoncer la publication chez Frontiers in Pharmacology et la mise en ligne d’un numéro spécial intitulé « Matricellular Receptors as Potential Targets in Anti-Cancer Therapeutic Strategies ».

Ce livre, composé d’articles de revue et de recherches originales, présente les données récentes obtenues dans l’étude des récepteurs membranaires dont les rapports, directs ou indirects, avec la matrice extracellulaire modulent le comportement cellulaire. Il fait également le point sur l’identification de ces récepteurs « matricellulaires » comme cibles thérapeutiques dans le contexte de pathologie tumorale.
De nombreux membres de la SFBMEc ont contribué à sa réalisation.

La version electronique de cet ouvrage « Matricellular Receptors as Potential Targets in Anti-Cancer Therapeutic Strategies » est consultable/téléchargeable ici.

Hervé Emonard, Stéphane Dedieu and Laurent Duca are pleased to announce the publication by Frontiers in Pharmacology of a special issue entitled « Matricellular Receptors as Potential Targets in Anti-Cancer Therapeutic Strategies ».

This book, composed of bibliographic reviews and original reports, present recent data on the cell membrane receptors which mediate signaling from the extracellular environment to modulate cell behavior. It also highlights the identification of these « matricellular » receptors as therapeutic targets in the context of tumor pathology.
Many members of the SFBMEc contributed to its realization.

The ebook « Matricellular Receptors as Potential Targets in Anti-Cancer Therapeutic Strategies » can be consulted/downloaded here.

Enrichment of Extracellular Matrix Proteins from Tissues and Digestion into Peptides for Mass Spectrometry Analysis

Naba A, Clauser K.R,and Hynes R.O. Enrichment of Extracellular Matrix Proteins from Tissues and Digestion into Peptides for Mass Spectrometry Analysis. J. Vis. Exp, 2015, (101), e53057, doi:10.3791/53057

Lien vers la vidéo: ici

Lien vers le protocole: ici

The Extracellular Matrix: Tools and Insights for the “Omics” Era

Naba A, Clauser K.R, Ding H, Whittaker C.A, Carr S.A, and Hynes R.O. The Extracellular Matrix: Tools and Insights for the « Omics » Era. Matrix Biology, 2015, pii: S0945-053X(15)00121-3

Liens vers l’article (open access):

• The matrisome is defined as the ensemble of 1000 + genes encoding ECM and ECM-associated proteins.

• Bioinformatic and experimental approaches to study the ECM/matrisome are discussed.

• We introduce a novel website and database MatrisomeDB to centralize resources on the matrisome.

• We present a draft of an ECM atlas compiling proteomics data on the ECM of 14 different tissues and tumors.

• “Omics” data provide novel insights into ECM functions in development, homeostasis and disease.


Special issue of Cell Adhesion & Migration on Tenascins

Tenascins_meetingFollowing the successful meeting organized last year in May 2014, a special issue of Cell Adhesion & Migration on Tenascins: Defining their role in tissue homeostasis and cancer has been published [Volume 9, Issue 1-2, 2015]. This issue is co-edited by Kim Midwood & Gertraud Orend and you access it on the publisher’s website. The foreword signed by the co-editors is in open access.



Volume spécial consacré aux protéoglycanes dans Matrix Biology (Proteoglycan Biology, April 2014)

Un volume spécial consacré aux protéoglycanes et édité par Liliana Schaefer vient d’être publié dans Matrix Biology (Proteoglycan Biology, volume 35, pages 1-276, April 2014). Ce volume résume les récents développements dans la biologie des protéoglycanes et du hyaluronane présentés lors de la 8ème conférence sur les protéoglycanes organisée par LiLiana Schaefer (Francfort, Allemagne) et John Couchman (Copenhague, Danemark) à Francfort du 25 au 29 août 2013. Vous pouvez le consulter à l’adresse suivante :

Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters

Alexandra Naba, Karl R. Clauser, John M. Lamar, Steven A. Carr and Richard O. Hynes.
Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters. eLife, 2014, 3:e01308

Lien vers l’article:

Lien vers le résumé:



Naba A, Clauser KR, Hoersch S, Liu H, Carr SA, Hynes RO.
The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.
Mol Cell Proteomics. 2011 Dec 9.
Koch Institute for Integrative Cancer Research at MIT, United States.

Lien vers PubMed.


Bignon M, Pichol-Thievend C, Hardouin J, Malbouyres M, Bréchot N, Nasciutti L, Barret A, Teillon J, Guillon E, Etienne E, Caron M, Joubert-Caron R, Monnot C, Ruggiero F, Muller L, Germain S.
Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane.
Blood. 2011 Oct 6;118(14):3979-89. Epub 2011 Aug 11.
PMID: 21835952
College de France, Center for Interdisciplinary Research in Biology, Paris, France.

Lien vers PubMed.


Langlois B, Perrot G, Schneider C, Henriet P, Emonard H, Martiny L, Dedieu S.
LRP-1 promotes cancer cell invasion by supporting ERK and inhibiting JNK signaling pathways.
Université de Reims Champagne-Ardenne, CNRS UMR 6237 MEDyC, Laboratoire SiRMa, Campus Moulin de la Housse, Reims, France.

Lien vers PubMed.


Chautard E, Fatoux-Ardore M, Ballut L, Thierry-Mieg N, Ricard-Blum S.
MatrixDB, the extracellular matrix interaction database.
Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS-Université Lyon 1, IFR 128 Biosciences Gerland-Lyon Sud, 7 passage du Vercors 69367, Lyon Cedex 07 and TIMC-IMAG/TIMB, UMR 5525 CNRS-Université Grenoble 1-Faculté de Médecine, 38706 La Tronche Cedex, France.

Lien vers PubMed.