Archives de l’auteur : Jessica Jonquet

Joint Meeting of the French and German Societies for Matrix Biology

Du 26 Mai au 28 Mai 2021, l’inscription est gratuite, mais est obligatoire : http://matrixbiology2021.univ-lyon1.fr/fr

La date limite pour soumettre un résumé (en ligne exclusivement) est le 30 Avril 2021. Toutes les instructions sont sur le site : http://matrixbiology2021.univ-lyon1.fr/fr/pages/matrix-biology-abstract.

Pour rappel, la SFBMEc récompensera l’excellence de travaux sur la matrice extracellulaire d’un/e jeune chercheur/se lors d’une session plénière Young Investigator Award de ce congrès. Date limite pour postuler : 20 Avril 2021

Appel Bourse de fin de thèse dans le domaine de l’athérosclérose/lipide/biologie vasculaire NSFA

La Nouvelle Société Francophone d’Athérosclérose, comme chaque année,  propose des financements de fin de thèse sous forme de CDD d’une durée allant de 3 à 12 mois maximum non-renouvelable. Les dossiers de candidature ainsi que le règlement sont consultables et téléchargeables sur le site de la NSFA: 

https://www.nsfa.asso.fr/bourses/financements-fin-de-these-nsfa-2021/

Vous avez jusqu’au 01 juin pour envoyer votre dossier a l’adresse indiquée sur le site.

Attention, les dates d’auditions pour cette année ne sont pas encore fixées. Elles vous seront communiquées ultérieurement.

Le comité d’organisation

Offre de thèse : Étude des mécanismes d’assemblage du site actif de l’hydrogénase à [FeFe]

Une offre de thèse (CFR-CEA) est ouverte dans l’équipe Métalloprotéines de l’institut de Biologie Structurale à Grenoble (https://www.ibs.fr/research/research-groups/metalloproteins-group/), pour travailler sur l’étude structural des mécanismes d’assemblage du site actif de l’hydrogénase à [FeFe].

Pour plus d’informations cliquez ICI

A doctoral position is available in the Metalloproteins Unit (MU) at the Institut de Biologie Structurale (IBS) in Grenoble – France (https://www.ibs.fr/research/research-groups/metalloproteins- group/) to work on the structural study of the the [FeFe]-hydrogenase active site assembly machinery.

For more information click HERE

SAVE THE DATE

SAVE THE DATE

May 26 – 28, 2021

The French and the German Societies for Matrix Biology organise a joint and online scientific meeting free of charge from May 26 to May 28, 2021.

Numerous opportunities for early career and PhD student to present their work !

Information to come on the SFBMEc website.

Keep up to date and stay in the loop !!!

BMS Oxford fellowship in Matrix Biology

BMS Oxford Research Fellow
NDORMS, Kennedy Institute of Rheumatology, Roosevelt Drive, Headington, Oxford OX3 7FY
Grade 7: £32,817 – £40,322 p.a.

More information: BMS fellowship in Matrix Biology

CDD ingénieur de 18 mois à l’IBS, Grenoble

Le groupe SAGAG recrute un ingénieur de recherche, titulaire d’un doctorat, et possédant une bonne expérience en biochimie des protéines et des oligosaccharides pour étudier les enzymes de biosynthèse des héparanes sulfates.

Pour en savoir plus et postuler, rendez-vous sur le site :
https://emploi.cnrs.fr/Offres/CDD/UMR5075-JERGAU-005/Default.aspx

ATER ENS de Lyon: poste à pourvoir au 1er septembre 2021

Un poste d’attaché temporaire d’enseignement et de recherche (ATER) est ouvert au département de biologie de l’ENS de Lyon pour la campagne d’emploi 2021. Il s’agit d’un poste pour un an éventuellement renouvelable une fois, avec 192hTD de service d’enseignement.

Les profils d’enseignement et de recherche associés sont très ouverts: le/la candidat.e est appelé.e à rejoindre un des laboratoires de biologie de l’ENS de Lyon (CIRI, IGFL, LBMC, RDP) pour participer aux travaux de recherche de l’une de leurs équipes. Le/la candidat.e devra impérativement prendre contact avec le département d’enseignement d’une part et le laboratoire/l’équipe d’accueil qu’il souhaite rejoindre et proposer un projet de recherche établi en concertation avec l’équipe d’accueil.

Profil et instructions de candidature sur le site internet de l’ENS de Lyon:
http://www.ens-lyon.fr/sites/default/files/2021-01/0088%20Biologie%20-%20Profil%20de%20poste%20ATER%202021%20Session%201.pdf

Attention : date limite de candidature le 16 février 16h.

Full time post-doctoral position at the Centre Scientifique de Monaco

We are seeking a highly motivated postdoctoral fellow in coral cell biology to join the Coral Physiology team at CSM and participate in projects related to the biology of calcifying cells in tropical corals. Our goal is to look at coral calcification at the cellular level and more specifically 1) investigate the biology of  primary cilia in different tropical coral species and under different experimental conditions and 2) investigate the processes of endo/exocytosis in the model tropical coral Stylophora pistillata. Ultimately, we aim at understanding how these cellular processes are linked to the physiology of calcification in tropical corals.

Candidate profile:

  • PhD degree in  cell Biology or cell Physiology,
  • Experience in electron and confocal microscopy techniques,
  • Good knowledge of molecular and bioinformatics approaches,
  • Scientific background on primary cilia and/or exo/endocytosis processes and/or related aspects of cell biology/cell physiology,
  • A background in studying calcifying organisms is an advantage,
  • Ability and willingness to conduct laboratory work,
  • Excellent written and oral communication skills in English,
  • Ability to write publications for peer-reviewed scientific journals,
  • Ability to work independently and self-guided, but likewise within an interdisciplinary research team.

Initial appointment (ca. 2800 euros net + health insurance and pension) is for 12-months, with possibility of extension for a second year (subject to funding and performance). It will ideally start in March/April 2021. The position is supervised by Dr. Sylvie Tambutté (team leader), in collaboration with all team members.

Submission Documents:
Interested individuals are invited to submit an application package including :

  • a motivation letter explaining reasons for applying and how they meet the hiring criteria outlined above,
  • a research project of 1 to 2 pages including the description of the costs associated to the proposal (excluding the salary),
  • a CV,
  • a copy of PhD certificate,
  • name and address of at least two referees.

These application documents must be submitted as a single pdf to:
Sylvie Tambutté stambutte@centrescientifique.mc
Application Deadline: 28th February.
Note: application review will begin immediately.
The position will remain open until the position is filled.
Further information about the research focus of the Physiology team can be obtained at http://www.centrescientifique.mc

Call for a chair position on Bioengineering and Tissue Engineering with a focus on bio- and 3D printing

Applications are open to specific fields. This call concern a position on Bioengineering and Tissue Engineering with a focus on bio- and 3D printing (Health Sciences and technologies department and College of Science and Technology). Please find more information in the document section.
 
This scheme aims to facilitate the recruitment of young lecturer-researchers on the basis of job profiles pre-identified by the institution in emerging and highly multidisciplinary disciplines or where there are strong international stakes. The scheme is part of a talent management policy shared with partner institutions, particularly research organizations. 
 
In this pre-recruitment chair system, the successful candidate will first be recruited on a fixed-term contract as a lecturer-researcher, during which his/her work will be monitored and evaluated according to the criteria defined during recruitment. The success of the evaluation could lead to a statutory lecturer-researcher position via the standard recruitment procedure (competitive procedure).
 
Candidates for the Chair are also encouraged to apply for other French and international funding that can be combined with the funding from the University of Bordeaux (ERC, ATIP-Avenir, ANR JCJC, etc….).
 
Funding
The chair will be funded for a period between three and five years maximum
The funding will cover the salary of the project leader for a maximum of 5 years.
Project-related costs (running costs, equipment and/or for the recruitment of staff dedicated to the project) may complete the Chair’s budget, within the framework of this program or within the framework of external funding (regional chair, Atip Avenir). Project related costs could be up to 200,000 euros on average for 5 years.

 

Closing date : 2021/02/22 at 12:00

More information : https://aap.u-bordeaux.fr/siaap/pub/appel/view/150

Research Professor position: research on burn care at the CHUM Research Center Faculty of Medicine, Université de Montréal

Le Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM) en lien avec la Faculté de médecine de l’Université de Montréal et le Centre d’expertise des victimes de brûlures graves de l’ouest du Québec désire recruter un professeur chercheur adjoint ou agrégé dans le domaine de la recherche sur les soins aux grands brûlés. Le ou la candidat(e) doit détenir les compétences et l’expérience des approches en recherche fondamentale sur les soins aux grands brûlés.

La description du poste est disponible aux liens suivants :
En français : https://www.chumontreal.qc.ca/sites/default/files/inline-files/poste-de-professeur-chercheur-fr-version-1_0.pdf
En anglais : https://www.chumontreal.qc.ca/sites/default/files/inline-files/research-professor-position-en-version_0.pdf

12 Early Stage Researcher Positions in the Marie Skłodowska-Curie Innovative Training Network SkinTERM – Skin Tissue Engineering and Regenerative Medicine

We are recruiting 12 highly motivated and excellent early stage researchers (ESRs) for the Innovative Training Network “SkinTERM”, an EU Horizon 2020 Marie Skłodowska-Curie Actions funded project.

SkinTERM stands for Skin Tissue Engineering and Regenerative Medicine and aims to convert the normal mode of skin repair into skin regeneration by delivering excellently and multidisciplinary trained scientists able to take this research area to the next level. Today’s standard treatment of skin burns and large trauma is transplantation of autologous split-thickness skin. This carries a number of serious drawbacks, including pain, mobility-limiting contractures and disfiguring scars. SkinTERM aims to address wound healing in a completely different way, recapitulating regeneration rather than repair. Skin organogenesis will be induced by key elements taken from the extracellular matrix of foetal skin and the skin of species that exhibit no scarring in the regeneration process, and by employing (stem) cells from relevant cellular origins.

The project aims to create a new generation of entrepreneurial, multidisciplinary and intersectorially trained scientists with excellent career prospects in either academia, industry or government. Early stage researchers trained in this programme will be able to drive this research area further towards clinical translation in Europe.

More information on SkinTERM partners, individual ESR projects and application procedure can be found at www.SkinTERM.eu.

Criteria

Please ensure that you fulfil the following eligibility criteria for ESR positions in H2020 MSCA-ITNs, as ineligible candidates cannot be considered:

  • The candidate must not have resided or carried out his/her main activity (e.g. work, studies, etc.) in the country of the host institution of interest (see individual project descriptions) for more than 12 months in the 3 years immediately before the recruitment date.
  • The candidate must hold a Master’s degree, be in the first four years of his/her research career and not have a doctoral degree.

Furthermore, the candidate is expected to develop into an independent researcher and is:

  • A team player able to work collaboratively in a multidisciplinary consortium.
  • Able to work independently and well-structured.
  • Proficient in written and spoken English.
  • Willing to move to the country of the host institution of interest and work for a prolonged. period abroad as part of the planned secondments (see individual project descriptions).

Benefits

  • Enrolment in local PhD training programme
  • Extensive SkinTERM cross-sectorial training programme including soft skill development and specialist techniques
  • Contract of 36 months at one of the host institutions
  • Attractive salary including a living allowance, a mobility allowance and, if applicable, a family allowance as specified in the Horizon 2020 Marie Skłodowska-Curie actions Work Programme 2018-2020.

How to apply

Application deadline: Please send your application before December 21, 2020.

Application: Applications should be submitted via the APPLY link at the individual ESR position descriptions on www.SkinTERM.eu. You may apply for multiple ESR positions, but need to motivate for each position why you are interested in the particular position and what you can offer the project. Your application must include the following documents:

  • Motivation letter for the PhD position of interest
  • CV
  • Letters of recommendation (at least two)
  • Copies of diplomas, including grades

Note that ESR project 9  requires additional application for a Postgraduate Course at Durham University: https://www.dur.ac.uk/study/pg/apply/

Note that ESR projects 10, 11 and 12 require additional application for the Life Science Zurich Graduate School of UZH: https://www.lifescience-graduateschool.uzh.ch/en.html

Selection procedure: The first selection round will be an online interview with the representatives of the host institutions and of the secondments. The two best candidates will give a scientific presentation on a subject relevant for the ESR project. Candidates will be selected based on:

  • Outstanding academic ability
  • Requested skills and experience for the ESR project of interest
  • Motivation of the application for the ESR position of interest

Starting date: Successful applicants are expected to start on March 1, 2021.

Contact: For more information on the SkinTERM project and application procedure please contact Danique Hof MSc, project manager SkinTERM at danique.hof@radboudumc.nl.

#THEmeshwork : réseau international de jeunes chercheurs dans le domaine de la matrice extracellulaire

Création un réseau international de jeunes chercheurs dans le domaine de la matrice extracellulaire appelé #THEmeshwork. Notre but est de favoriser l’interaction entre les jeunes chercheurs / étudiants / jeunes PIs et de les aider dans le développement de leur carrière.
Vous trouverez plus de détails concernant notre projet dans le flyer ci-dessous.

THEmeshwork team
Nuno Coelho
Julie Di Martino
Valerio Izzi
Tia Jones
Pauline Nauroy
Ines Velazquez Quesada
Chloé Yeung

Recherche des candidats en vue de la création d’un poste de Professeur des Universités en Biologie Cellulaire à l’Université Claude Bernard Lyon 1

Le Laboratoire de Biologie Tissulaire et Ingénierie thérapeutique (LBTI, UMR 5305 CNRS et Université Lyon 1; https://lbti.ibcp.fr/) recherche des candidats en vue de la création d’un poste de Professeur des Universités en Biologie Cellulaire à l’Université Claude Bernard Lyon 1 (section CNU 65). Le (la) candidat(e) devra avoir une solide expertise en Biologie Cellulaire, d’une manière générale, pour les enseignements en Licence, et particulièrement en Biologie Tissulaire, Interactions cellules-matrice extracellulaire, voire Mécanotransduction, pour des enseignements en Master. Le (la) candidat(e) renforcera l’axe « Réparation Tissulaire » de l’Unité et développera un projet en accord avec les thématiques développées par l’Unité, qui consiste à (1) comprendre les mécanismes fondamentaux de l’organisation d’un tissu, (2) comprendre et évaluer la capacité de réponse des tissus à différents types d’agressions extrinsèques et/ou intrinsèques et (3) proposer et tester des approches thérapeutiques innovantes dans le cadre de l’ingénierie tissulaire et de la médecine régénérative. Ainsi, une solide expertise dans l’étude des dialogues dynamiques cellule-cellule ou cellules-microenvironnements au cours des processus d’homéostasie et de réparation tissulaires est demandée.

Contact Recherche : Dominique SIGAUDO-ROUSSEL (dominique.sigaudo-roussel@ibcp.fr) Contact Enseignement : Ulrich VALCOURT (ulrich.valcourt@ibcp.fr)

The Tissue Biology and Therapeutic Engineering Laboratory (LBTI, UMR 5305 CNRS and Université Lyon 1; https://lbti.ibcp.fr/ ) is looking for candidates for a Full Professor position in Cell Biology at the University of Lyon (CNU section 65). The candidate should have a strong expertise (1) in general Cell Biology, for the teaching in Bachelor’s degree, and (2) in Tissue Biology, Cell-extracellular Matrix Interactions and/or in Mechanotransduction, to give lectures in the Master program. The candidate will strengthen the “Tissue repair” axis of the LBTI Unit research and will develop a research project in accordance with the topics that are developed in the research unit :(1) understanding the fundamental mechanisms of tissue organization, (2) understanding and assessing tissue response(s) to different extrinsic and intrinsic insults, and (3) proposing and testing innovative therapeutic approaches in the context of tissue engineering and regenerative medicine. A strong expertise in the study of dynamic cell-cell or cell-microenvironment cross-talks during homeostatis or tissue repair processes is required.

Research contact: Dominique SIGAUDO-ROUSSEL (dominique.sigaudo-roussel@ibcp.fr) Teaching contact: Ulrich VALCOURT (ulrich.valcourt@ibcp.fr)

 

PhD student position in Tissue Repair & Wound Healing Biology

A 3-years PhD student position is available in the group of Patricia Rousselle in the Tissue Biology and Therapeutic Engineering Unit at the Institut de Biologie et Chimie des Protéines (IBCP), Lyon. The topics of research developed will focus on: i) Analysis of the biological properties of a 3D-skin equivalent model, ii) mechanisms involved in skin repair upon treatment with matrix biomimetic- scaffolds in animal models. The LBTI (www.lbti.fr) is well equipped for cell biology, molecular biology and biochemistry and belongs to a larger campus (SFR BioSciences Gerland – Lyon Sud (US8 / UMS3444, https://www.sfr- biosciences.fr/), giving access to state-of-the-art core facilities in areas ranging from animal models to protein science such as animal facilities, bioimaging, biomolecular analysis, proteomics, structural biology and production and analysis of proteins. Working languages of the laboratory are English and French.

We are looking for enthusiastic, self-motivated individuals with a background in tissue and cell biology and Imaging techniques. Know-how in cell culture and microscopic techniques is recommended. Excellent adaptability to team-work in different environments and mobility is absolutely required.

Starting date: January, 2021 or earlier (to be discussed).

Please send your CV, names of referees and a short informal description of yourself as a single PDF file to: patricia.rousselle@ibcp.fr
Dead line for applications: September 7, 2020.

European Tissue Repair Society 2020

Le congrès annuel de l’European Tissue Repair Society se tiendra à Lyon du 17 au 19 Septembre 2020. Une pré-conférence pour les jeunes chercheurs se tiendra la veille du congrès.

De nombreuses bourses de voyage et prix seront attribués pour les jeunes chercheurs, dont un prix de la SFBMEc pour récompenser un travail en lien avec la Matrice Extracellulaire.

ISMB Calls for Distinguished Investigator Award Nominees and for New ISMB Council Members

ISMB announces the Opening of the Call for Nominations for the 2020 Distinguisher Investigator Award.

This Award is given by the International Society for Matrix Biology to an established researcher in recognition of important lifetime achievements in the field of Matrix Biology.

A list of the former winners is given at https://ismb.org/prizes/

The Awardee will give the ISMB Distinguished Investigator Lecture at the 2020 ASMB Biennial Conference, Nov. 8-11th 2020 in St. Louis, Missouri.

ISMB members are invited to send in their nominations for the Distinguished Investigator Awardee 2020. Please provide:

  1. A full curriculum vitae of the nominee, including a list of their publications.
  2. A letter of nomination that highlights key lifetime research achievements in the field of Matrix Biology.

These nominations will be voted on by the ISMB Council.

Please send nomination packs to the ISMB Secretary (jo.adams@bristol.ac.uk) by 31stJan. 2020 at the latest.

 

Call for Nominations for New ISMB Council Members.

There are two vacancies to serve on the ISMB Council and we are calling for nominations or volunteers to fill these. If you wish to nominate someone, please make sure first that they agree to be nominated.

The vacancies are for:

1 regular ISMB Council member (from any region of the world) and

1 early-career Council member (from any region of the world).

The main responsibilities of regular Council members are to promote the Aims of ISMB in the international matrix biology community in general, and to take part in ISMB Council meetings by teleconference or in-person at conferences, to vote in the Awards processes, and to take part in nominations for Executive officers of Council. The ISMB statutes are available at https://ismb.org/bylaws/

The early-career Council member will have involvement in the Communications sub-group and social media activities and in raising awareness of ISMB amongst early career researchers, and will take part in ISMB Council meetings by teleconference or in-person at conferences.

All Council members serve a 3 year term in the first instance, with the option of renewal for a further 3 years.

Please send names, contact details and biosketch of Council nominees to the ISMB Secretary, jo.adams@bristol.ac.uk by 27th January 2020.

Soutenance d’HDR de Caroline REYNAUD

Caroline REYNAUD

Laboratoire LYOS INSERM UMR 1033 – Equipe 2 Bone, Cancers and Metastases – Université de Lyon

Rôle des Lysyl Oxydases dans la progression tumorale

Le Docteur Caroline REYNAUD a soutenu son Habilitation à Diriger des Recherches le 19 novembre 2019 devant un jury composé de :

  • Pr Ulrich VALCOURT, président
  • Dr Catherine MONNOT, rapporteur
  • Pr Maxime LEHMANN, rapporteur
  • Pr Laurent DUCA, rapporteur
  • Dr Philippe CLEZARDIN, examinateur

Call for Nominations for 2020 Rupert Timpl Award

ISMB IS PLEASED TO ANNOUNCE THE OPENING OF THE COMPETITION TO IDENTIFY THE 2020 RUPERT TIMPL AWARD WINNER.

The International Society for Matrix Biology created in 2004 a prize dedicated to the memory of the outstanding matrix biologist, Rupert Timpl, who died on October 20th, 2003. The prize is called the « Rupert Timpl Award ».

The prize is awarded biannually at the occasion of the Matrix Biology Europe /FECTS meeting. It is given to a young matrix biologist at an early stage of their scientific career, in general below 40 years of age, who has published the « BEST PAPER IN THE FIELD OF MATRIX BIOLOGY » during the two years prior to the year of the MBE/FECTS meeting.

As an integral part of the programme, the laureate will give a plenary lecture, called the Rupert Timpl Lecture, at the 2020 MBE meeting to be held in Florence, Italy, 24-28 May, 2020.

A prize of EUR 2,000 will be given, which is generously sponsored by Elsevier, the publisher of Matrix Biology.

ISMB MEMBERS ARE INVITED TO SEND THEIR NOMINATIONS FOR THE AWARDEE TO THE ISMB SECRETARY (JO.ADAMS@BRISTOL.AC.UK) BY 31ST DEC. 2019.

The nominations will be voted on by ISMB Council and the winner will be
announced in January 2020.

Eligibility: The nominee should be a young matrix biologist at an early stage of their scientific career, in general below 40 years of age, who has published the « BEST PAPER IN THE FIELD OF MATRIX BIOLOGY » during 2018 and 2019.

Please provide for your nomination:

A letter of support that includes a rationale for the nomination and the
specific paper published in 2018 or 2019 for consideration.

The nominee’s CV, with inclusion of a full list of publications.

With best wishes,

Jo Adams

ISMB Secretary.

PhD position : Targeting breast cancer metastasis – University of Liège (Belgium)

The Laboratory of Tumor and Developmental Biology, GIGA-Cancer, at the University of Liège (Belgium) has an opening for a PhD candidate on breast cancer resistance to targeted therapies (PI: Nor Eddine SOUNNI, team cancer and metabolism)

Topic: Targeting breast cancer metastasis

Project summary:

Despite advances in targeted therapies against HER2+, the presence of intrinsic and/or acquired resistance to anti-HER2 therapy remains an important challenge in breast cancer. In the triple negative breast cancer (TNBC), while it expresses high level of EGFR, anti-EGFR targeted therapies in combination with chemotherapies were generally unsatisfactory in clinical trials. This project is based on our recent paper (Foidart et al. 2019, Clinical Cancer Research) in which we demonstrated the clinical relevance of 3 molecules, EGFR, MT4-MMP and RB in TNBC and showed efficacy of targeting EGFR and CDK4/6 in 50% of TNBC expressing MT4-MMP, EGFR and RB. The new project aim is to understand mechanism(s) of MT4-MMP in breast cancer progression. We will investigate the repertoire of substrates of MT4-MMP by iTRAQ and MS analysis. We will validate the role of the target substrate and perform functional assays for evaluating their role in breast cancer proliferation and migration in vitro, and tumor growth and metastasis in vivo. Our ultimate goal is to propose new therapies for the untreatable TNBC and for therapy resistant HER2+ breast cancer.

Technically, the project involves cell culture, siRNAs, proliferation and migration assays, western blots and immunoprecipitations, and in vivo study using xenografts and PDX for tumor growth and metastasis.

The ideal candidate will be highly motivated and have a Master in Biomedical Sciences/Biology/Biochemistry.

The available funding is 4 years Télévie grant (F.R.S-FNRS) starting on October 1st 2019.

Interested candidates should send their résumé and application letter to Dr. Nor Eddine SOUNNI (nesounni@uliege.be).

PhD student position in immunology, skin biology and extracellular matrix Department of Dermatology, University of Freiburg

We are looking for a highly motivated PhD student interested in immunology and the extracellular matrix to join our dynamic and international team at the Department of Dermatology, Medical Center – University of Freiburg, Germany. The project will focus on delineating the role of the lymphoid extracellular matrix in maintenance of systemic and skin immune homeostasis. Genetic skin blistering diseases will be used as models. For the studies, analyses of patient-derived samples, ex vivo and in vivo models will be employed. Practical knowledge of cell culture, basic immunological and biochemical analyses is needed; FELASA B certification or equivalent is an advantage. The position is fully funded for four years and part of a collaborative research center on immunology.

To apply, please send motivation letter with CV and contact information of three references to PD. Dr. Dimitra Kiritsi and Dr. Alexander Nyström

We are looking forward to your application!

Application deadline: August 1st.
Starting date: September 1st
Funded by: DFG, German Research Foundation
Duration: 4 years

Contact: Dr. Alexander Nyström alexander.nystroem@uniklinik-freiburg.de PD. Dr. Dimitra Kiritsi dimitra.kiritsi@uniklinik-freiburg.de

References:

Nyström A et al.,. 2018. Impaired lymphoid extracellular matrix impedes antibacterial immunity in epidermolysis bullosa..Proc Natl Acad Sci U S A.

Kühl T et al.,. 2016. Collagen VII Half-Life at the Dermal-Epidermal Junction Zone: Implications for Mechanisms and Therapy of Genodermatoses. J Invest Dermatol.

Föll MC et al., 2018. Identification of tissue damage, extracellular matrix remodeling and bacterial challenge as common mechanisms associated with high-risk cutaneous squamous cell carcinomas..Matrix Biol

Spörrer M et al.,. 2019. Treatment of keratinocytes with 4-phenylbutyrate in epidermolysis bullosa: Lessons for therapies in keratin disorders. EBioMedicine.

The University of Manchester : PhD opportunities

CELL-MATRIX SIGNALLING IN SKIN REPAIR

https://www.findaphd.com/phds/project/cell-matrix-signalling-in-skin-repair/?p109406

PROTEASES AS MEDIATORS OF TISSUE REPAIR

https://www.findaphd.com/phds/project/proteases-as-mediators-of-tissue-repair/?p109401

The closing date is the 7th June.

DR MICHAEL J SHERRATT
Senior Lecturer in Molecular Biochemistry
Associate Lead for PEP Years 1 and 2
Division of Cell Matrix Biology and Regenerative Medicine
School of Biological Sciences
Faculty of Biology Medicine and Health
The University of Manchester I Room 1.529, Stopford Building
Oxford Road
Manchester M13 9PT
Tel (+44) 161 275 1439

Offre de thèse sur les ostéocytes à Bordeaux

Rôle des ostéocytes dans la régénération osseuse assistée par les biomatériaux.

Voici une offre de thèse sur les ostéocytes à l’université de Bordeaux dans l’équipe Interfaces tissu hôte / produits d’ingénierie tissulaire de l’unité de recherche Bioingénierie tissulaire.
Attention, les candidats souhaitant postuler doivent s’inscrire au concours de l’école doctorale avant fin mai et être bien classés.
Pour tout renseignement, contacter Delphine Maurel : delphine.maurel@u-bordeaux.fr

Post-doctoral position : 3D Electrostimulable polymeric scaffolds for drug screening-applications

A two-year postdoctoral position is opening at the Institute of Materials (iMat) of the University Paris-Seine (Cergy-Pontoise). The project includes two labs of iMat: LPPI (Polymer chemistry) and ERRMECe (Biology)

Context
In vivo, cells are surrounded by the extracellular matrix (ECM), a 3D-meshwork of macromolecules. A great variety of dynamic biochemical, biophysical, topographical and electrical clues emanates from ECM. They govern cell survival, differentiation and others behaviors, and subsequently physiopathological processes. Especially, the microenvironment modulates cell phenotype and could subsequently orient cells’ response to drug agents and targeted therapies[1]. To take into account this native 3D-environment in cell-based assays, various supports have been developed. They are classified as scaffold-free (like spheroids) or scaffold-based supports (hydrogels, porous/fibrous scaffold) and are made respectively from natural ECM-derived molecules or synthetic material[2]. Among common synthetic commercial scaffolds, there are microfabricated scaffolds and the widely described electrospun fiber mats. Poly(High Internal Phase Emulsion) (polyHIPEs) presenting interconnected porous structures, have been described also as really promising 3D templates [3,4] but are, up to now, only available at laboratory scale.

Despite their advantages in terms of robustness, reproducibility and tunability in comparison to natural ECM-derived materials, these synthetic scaffolds rarely incorporate ECM molecules, thus losing the “biochemical component” of cell microenvironment. Moreover, such scaffolds display limited and uncontrolled dynamic and often lack the combined regulatory inputs as porosity, elasticity, topography, or electrical clues from the ECM that all contribute to modulating cell survival and functions[5]. In this context, the emergence of electroactive materials is of critical interest to mimic the environment of demanding cells regarding mechanical, morphological or electrical stimulation. Such materials represent a fast growing field and rely on the coatings of 3D porous structures with conducting materials. For instance, graphene coating on silk fibroin fiber mats, providing electrical conduction, improved the differentiation of PC-12 cells into neural phenotypes[6]. Coating with a conducting polymer (polyaniline) on similar scaffolds allowed electrical stimulation and enhanced differentiation of myogenic (muscle) C2C12 cells[7]. In addition to simple electrical conduction, conducting polymers (CPs), as electroactive polymers, can also provide additional functions rarely described in this field. Indeed, they are also able to change shape/volume and/or mechanical properties when electrochemically oxidized or reduced. Actually, when CPs are stimulated using low potentials (~ 1V), exchanges (insertion/expulsion) of counter-ions with surrounding electrolyte takes place, leading to electrochemically controllable volume changes[8] thus, allowing both electrical and mechanical stimulations.

LPPI has described the first rubbery electroactive electrospun scaffolds based on elastomer (Nitrile Butadiene Rubber) and polyethylene oxide (PEO) functionalized by a conducting polymer (poly(3,4- ethylenedioxythiophene) (PEDOT)[9,10]. Not evaluated yet as electroactive cell culture scaffolds, they presented promising actuation and beating functionalities in the presence of phosphate buffered saline (PBS). Preliminary data suggest their cytocompatibility. More recently conducting polymer coating has been used by Jager et al. to provide mechanical beating functionality to poly(lactic-co- glycolic acid) (PLGA) electrospun fibers and resulted in increased expression of cardiac markers of stem cells[11]. Nevertheless this unique example of mechanically active culture scaffolds displayed limited volume variations due to the high stiffness of PLGA fibers, highlighting the need of soft and rubbery 3D templates for efficient electroactive behavior. It is worth mentioning that polyHIPEs have never been functionalized by any electroactive material contrary to electrospun fiber mats.

Project
In the frame of 3DEStim, we propose:

  • To develop 3D electroactive scaffolds for cell culture combining both electrical and mechanical stimulation. Such materials will be elaborated first from highly porous polyHIPE structures. A conducting polymer will be embedded into this matrix by oxidative chemical vapor phase polymerization of corresponding monomer.
  • To functionalize these scaffolds with adhesive ECM glycoproteins for displaying controlled properties and signal dynamic of in vivo cell environments. The cells responses to such ECM- containing scaffolds will be then studied.
  • To establish the proof of the concept of using such a device for drug response screening, firstly focusing on anticancer drug response, especially of ovarian cancer metastasis by tuning the scaffold to model their peritoneum implantation site, which displays in vivo dynamic resulting from breathing, digestion, and bodily movements.
    Thereafter, capitalizing on the acquired know-how, the 3D electoactive scaffold features as well as its ECM functionalization will be adapted to varied cell types in regard with the desired drug assays

Candidate Profile
Education

  • PhD in Polymer Chemistry or biomaterials

Competencies

  • Relevant research experience and demonstrated competencies in polymer and material
    synthesis. Experience in biomaterials and cell culture would be an asset
  • Track record of researcher dissemination including peer-reviewed publications
  • Ready to work according to best chemical or biology laboratory practices including lab safety.
  • Excellent project management, analytical, and report writing skills.
  • Excellent communication skills (oral, written, presentation).
  • Demonstrated ability to generate new ideas, concepts, models and solutions.
  • Collaborative skills, initiative, result oriented, organization, and capacity to work in an
    interdisciplinary environment.

Language

  • French and/or English

Requirement

  • less than 6 months in France since the last 3 years.

Contacts
Cedric.plesse@u-cergy.fr
Cedric.vancaeyzeele@u-cergy.fr
Johanne.leroy-dudal@u-cergy.fr

[1] Jebsen N. L. et al. Biomarker Panels and Contemporary Practice in Clinical Trials of Targeted Therapy. in Biomarkers of the Tumor Microenvironment. 2017
[2] Knight at al. J Anat. (2015), 227(6): 746–756.
[3] Moglia R.S. et al. Biomacromolecules (2014), 15, 2870−2878.
[4] McGann C.L. et al. Polymer (2017), 126, 408-418
[5] Kofron et al. J Physiol (2017), 595(12), 3891-3905.
[6] Aznar-Cervantes et al. Materials Science and Engineering: C (2017), 79, 315-325
[7] Zhang et al. Macromolecular Bioscience (2017) 17(9), 1700147
[8] Otero et al. J. Mater. Chem. B, 2016, 4, 2069–2085
[9] Kerr-Phillips et al. J. Mater. Chem. B, 2015,3, 4249-4258
[10] Kerr-Phillips et al. Biosensors and Bioelectronics, 2018, 100, 549-555, ISSN 0956-5663
[11] Gelmi et al. Adv. Healthcare Mater.2016, 5, 1471–1480

Offre de thèse au sein de l’équipe « Biocéramiques » de l’IRCER, UMR CNRS 7315 à l’Université de Limoges

Le sujet porte sur la « MISE EN PLACE D’UN MODÈLE BIOLOGIQUE DE CARACTÉRISATION _IN VITRO_ DES PROPRIÉTÉS ANGIOCONDUCTRICES ET ANGIOGÉNIQUES DE CÉRAMIQUES PHOSPHOCALCIQUES ». L’étudiant.e sera inscrit.e à l’École Doctorale n°609 Sciences et Ingénierie des Matériaux, Mécanique, Énergétique – SIMME de l’Université de Limoges.

Cette thèse sera effectuée au sein de l’équipe « Biocéramiques » de l’IRCER (Institut de Recherche sur les Céramiques [1]), UMR CNRS 7315 à l’Université de Limoges.

L’étudiant.e recherché.e sera titulaire d’un Master 2 Recherche, préférentiellement dans le domaine des Sciences de la Vie et plus particulièrement avec une spécialisation en biologie cellulaire et moléculaire. Il.Elle devra être sensibilisé.e au domaine des biomatériaux et devra être à même de travailler en équipe pluridisciplinaire.

Le candidat doit être autonome et doit avoir acquis une expérience en biologie cellulaire et moléculaire. Une bonne maîtrise des techniques de culture cellulaire et d’analyse du phénotype et des fonctions cellulaires est souhaitée.

Contacts (renseignements et candidature) : Amandine Magnaudeix et Eric
Champion (amandine.magnaudeix@unilim.fr ; eric.champion@unilim.fr )

PhD position in biochemistry : Design and investigation of adhesive proteins

Keywords: biomimicry, protein self-assembly, adhesion, surfaces.

  • Context and mission

In our daily lives, all conventional man-made adhesives are petrochemical products, which are toxic for the body and show limited efficiency in wet conditions, major drawbacks for biomaterials. In this project, we aim at producing adhesives effective in air and/or in wet conditions inspired by natural glues of some arthropods. This approach using simplified mimics of biological adhesives will facilitate better understanding of systems from which they are derived and could find applications in medicine as well as in biotechnology and industry.

Adhesive proteins of some arthropods have been identified. For these animals, the adhesion mechanism seems to be related to protein self-assembly on the surface. The molecular basis of this process has been elucidated by our team but its mechanisms remain to be elucidated. The goal of the PhD project is to produce adhesive proteins mimicking the natural one, to investigate the self-assembly process of these proteins and their adsorption/adhesion on materials. To achieve this goal, the project will involve a genetic engineering strategy, protein characterization approaches using biophysics and microscopies.

  • Candidate profile

We look for a highly motivated candidate with a strong knowledge in biochemistry, biophysics and/or in material science. The student should be able to work in a team, have very good writing skills (report, presentation…) and good knowledge of at least one of the language used in the lab: French, English.

  • The Laboratory and the team

The project will take place within “Equipe de Recherche sur les Relations Matrice Extracellulaire- Cellules” (ERRMECE: EA1391) from Cergy-Pontoise University (http://www.u-cergy.fr/errmece/), in collaboration with the “Laboratoire des Matériaux et du Génie Physique”(LMGP: UMR 5628) in the Grenoble Institute of Technology (http://www.lmgp.grenoble-inp.fr/), known worldwide for its expertise in material science.

The ERRMECE lab is composed of 18 staff members and is organized in three research groups:

– BioSan: this team works on biomatrerials, especially on layer by layer films and interpenetrated network technologies;

– BCMI: this team works on microbial biofilms and anti-fouling strategies;

– MecUp: this team works on human extracellular matrix in physico-pathological contexts. Hence the lab has extensive expertise in the study of different extracellular matrices, on their composition and function, in relationships with cells and the functionalization of materials. The PhD project proposes new “matrix-like” models for the ERRMECe lab and will reinforce the axis on protein- material interactions by the collaboration with the LMGP.

  • Contact

Charlotte Vendrely, Uni. de Cergy-Pontoise, ERRMECe ; charlotte.vendrely@u-cergy.fr

The position is available for 3 years starting from: October 1, 2019.

Application dead-line is: May 17, 2019.

Université de Cergy-Pontoise, EA 1391,
Equipe de Recherche sur les Relations Matrice Extracellulaire-Cellules-ERRMECe
Groupe MEC-uP
Maison Internationale de la Recherche Rue Descartes
95031 Neuville sur Oise Cedex France

Appel à candidatures Bourses ESDR 2019 – DEADLINE LE 30 AVRIL

La SFD a créé trois bourses de 1.500,00 euros pour financer la participation de jeunes dermatologues ou chercheurs au congrès de l’European Society for Dermatological Research.

Le prochain congrès « ESDR 2019 » aura lieu du 18 au 21 septembre 2019, à Bordeaux.

Vous trouverez ici un dossier de candidature pour cette bourse. Elle est réservée à un(e) jeune dermatologue, CCA ou interne ayant une communication orale ou affichée acceptée au congrès 2019, ou à un jeune chercheur médecin ou scientifique, participant, ou ayant participé à des projets de recherche en dermatologie, de moins de 35 ans, et ayant une bonne connaissance de l’anglais.

Les dossiers sont à renvoyer avant le 30 avril 2019 à Madame Anne-Laure Geoffroy, par mail sfd-jdp@sfdermato.com, ou par courrier : Bourses ESDR 2019, Maison de la Dermatologie, 10 Cité Malesherbes, 75009 Paris.

Professeur Marie BEYLOT-BARRY
Présidente de la SFD

Société Française de Dermatologie

Maison de la Dermatologie
10, Cité Malesherbes
75009 Paris FRANCE

INSERM international Workshop on GlycosaminoGlycans , Bordeaux, 19-21th of June 2019

Dulce Papy Garcia (Gly-CRRET, UPEC, Créteil) and Romain Vives (IBS, Grenoble) are glad to invite you to participate to the next INSERM (French national institute for Health Sciences) international workshop on Glycosaminoglycans that will take place in Bordeaux, on the 19-21th of June 2019.

The goal of this workshop is to put an emphasis on the technological developments and breakthroughs that led to progress in the understanding of GAG structure and biological functions, as well as the perspectives of applications in diagnostics and therapy.

The workshop will include 4 main sessions focusing on :

  • GAG Biosynthesis and Metabolism

Confirmed speakers : L. Kjellen (Uppsala Univ., Uppsala, Sweden) – L. Pedersen (South Carolina Univ., Chapel Hill, USA) – A. Malmström (Lund Univ., Lund, Sweden) – R. Vivès (IBS, Grenoble, France) – S. Fournel Gigleux (Nancy Univ., Nancy, France)

  • GAG-protein interactions and physiophatological conditions

Confirmed speakers : H. Lortat-jacob (IBS, Grenoble, France) – A. Vortkamp (Essen Univ., Essen, Germany) – D. Papy-Garcia (Université Paris Est, Créteil, France) – J. van den Born, (Groningen Univ., Groningen, The Netherlands) – P. Nieto (Spanish National Research Council, Sevilla, Spain)

  • Technological and methodological approaches for GAG analysis

Confirmed speakers : T. van Kuppevelt (Radboud Univ, Nijmegen, Pays-bas) – S. Ricard-Blum (Université de Lyon I, Lyon, France) – D. Bonnaffé (ICMMO, Orsay, France) – F. Noborn (Gothenburg Univ., Gothenbur, Sweden)

  • GAGs : from bench to bedside

Confirmed speakers : P. Albanese (Université Paris Est, Créteil, France) – Yongmei Xu (South Carolina Univ., Chapel Hill, USA) – F. Chiapini (OTR3, Paris, France)

Registration are open (deadline 15/04) and all details can be found on: Atelier INSERM 256

Special issue: MATRIX MODELING & REMODELING

Dear colleagues,

The special issue given below is online.
Thanks to the contributions by well known authors in the field,  another key area of matrix biology has been published.
Many thanks to editor-in-chief Renato Iozzo for giving us the  opportunity and his great support during all steps of this endeavor !

I hope it will be a useful for your future research.
All the best
Nikos

Matrix Biology
Volume 75, Pages 1-330, January 2019
Matrix Modeling and Remodeling
Edited by Nikos Karamanos